XI International Conference on AIDS|
July 7-12, 1996
Zekeng L., Tsague J.M.,
HIV-1 Group O Infection in Cameroon
ObjectiveTo determine the prevalence of HIV-1 group 0 infection in Cameroon and to compare it to that of HIV-1 group M.
MethodsSera was collected in several cities (Yaounde, Douala, Bertoua, Limbe, Banka) among selected groups including: pregnant women (PW) (anonymously); patients consulting in STD clinics (STD) (anonymously); patients attending tuberculosis units (TB) verbal consent; commercial sex workers (CSWs) (anonymously); students from high school (Stu) (Systematic screening); individuals from general population (GP) (anonymously). Specimens were tested for antibodies to HIV1 and HIV2 using Enzygnost HIV1/2 plus (Behring) (EIA 1+2).
Repeatedly reactive sera were retested by Enzygnost HIV1 competitive assays (Behring) (EIA 1). HIV-1 group 0 infection was suspected when the sera was EIA 1+2 positive and EIA I negative or borderline (ratio CO/OD<5). Confirmation was done by HIV-1 group 0 specific western blot (in house strips with MVP 5180 strain) and V3 loop peptides ELISA (Ant70 and MVP 5180).
ResultsOverall, 4500 specimens were screened during the last 14 months. Cases of HIV2 were found. The overall prevalence of HIV-1 group 0 infection was 0.6 % (ranging from 0 to 2 %) and accounting for 5 % of all HIV infection. The reactivity was mostly Ant70 like. Risk groups for HIV-1 group 0 appear to be similar to those of HIV-1 M infection (STD, CSWs, TB).
ConclusionThe global AIDS epidemic is spreading in Cameroon. Extended studies should be carried out nationwide to know the extent of HIV-1 group 0 and to monitor its trends.
Dr. L. ZEKENG
|XI Int. Conference on AIDS abstracts...||
Created: July 16, 1996|
Last modified: July 17, 1996
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